Tlaquepaque (Spanish pronunciation: [tlakeˈpake]), historically San Pedro Tlaquepaque, is a city and the surrounding municipality in the Mexican state of Jalisco.
During the 20th century it was absorbed by the outward spread of the state capital and is now a fully integrated part of the Guadalajara conurbation, lying only a few kilometres from the city centre. The city had a 2010 census population of 575,942, making it the third largest city in the state, behind only Guadalajara proper, and Zapopan, another city in the metro area. The municipality's area is 270.88 km2 (104.59 sq mi) and lies adjacent to the south side of Guadalajara. Its largest community besides Tlaquepaque is the town of Santa Anita, at the municipality's southwestern corner.